YIMLAMAI LAB
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Our Mission

​​Improving the Care of Children and Adults with Chronic Liver Disease


NIDDK Awards Yimlamai Lab 5 Year R01  to study interactions Between Liver Epithelial Cells and the Extracellular matrix in Inflammation and Fibrosis.


Yap/Taz promotes liver inflammation and fibrosis
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Activated hepatocytes are a major source of signals that drive cirrhosis,
but the biochemical pathways that convert hepatocytes
into such a state are unclear. We examine the role of the
Hippo pathway transcriptional coactivators Yes-associated protein
(YAP) and transcriptional coactivator with PDZ-binding
motif (TAZ) in hepatocytes to facilitate cell–cell interactions
that stimulate liver inflammation and fibrosis.
Our current projects are described in the ​Research Page. 

Mooring et al. (2020) Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis. Hepatology. 71(5): 1813-30. PMID: 31505040.

NIDDK Awards Yimlamai Lab R03 to Study Hepatocyte Stress and Inflammation.

We use transgenic mouse models to manipulate the expression of  genes in the Hippo Pathway. 
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Yimlamai, D.*, Christodoulou, C.*, et al.. (2014) Hippo Pathway Activity Influences Liver Cell Fate. Cell. 157, 1324-1338.  PMID: 24906150.

We  recently relocated to the Department of Pediatrics, Yale University School of Medicine

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